This report evaluates ATMP manufacturing scalability and cost-reduction strategies across the US and Europe (2025–2030). We quantify capacity build-out for cell, gene, and tissue therapies, model COGS reductions from closed-system automation, digital QMS, and lean cold-chain logistics, and estimate release-cycle time and failure-rate improvements. We also benchmark CapEx/Opex trajectories, labor productivity, and batch yields, plus bottlenecks in materials, analytics, and QA. Findings guide biopharma, CDMOs, payers, and regulators on where to invest to achieve scale, reliability, and lower price-per-patient.