This report quantifies the clinical trial tokenization opportunity in North America (2025–2030), focusing on patient compensation models, site/sponsor cashflow efficiency, and SEC compliance for tokenized incentives. We size platform revenue, model wallet adoption, payout latency, tax/AML automation, and retention impact, and evaluate regulatory pathways (Howey, Reg D/CF/A+, broker-dealer/custody, stablecoin risk). By 2030, tokenized payouts shift compensation from days to minutes, lifting retention and data completeness, while compliant tokens (KYC/AML, disclosures, tax reports) minimize legal exposure. We present ROI ranges, sensitivity to audit readiness, and procurement criteria for sponsors, CROs, and sites.